Factor VIII Market 2021 Expected to Rise at A Higher CAGR Value, Sales and Revenue

Factor VIII is a key factor of the intrinsic clotting cascade. Normal hemostasis requires at least a quarter of factor VIII activity. Although it is passed down from parents to children, about 1/3 of cases are caused by a spontaneous mutation, a change in a gene. Factor VIII is produced in liver sinusoidal cells and endothelial cells outside of the liver throughout the body circulating in the bloodstream in an inactive form in a stable noncovalent complex bound to von Willebrand factor (vWF). Global Factor VIII Market is segmented on the basis of type, disease management, application, and region. Hemophilia A, recessive X-linked coagulation disorder or Antihemophilic factor also called factor VIII (FVIII) deficiency or classic hemophilia, is a genetic disorder caused by missing or defective factor VIII, a blood clotting protein. It affects about 1 in 5000 males.

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Hemophilia A patients are treated with factor VIII concentrate for maintenance of normal hemostasis but unfortunately prophylactic treatment is not in general use around the world. Later on, recombinant factor VIII has been approved for therapeutic use, which lessens the risk of viral transmission. Factor VIII levels are of significance to measure not only to diagnose and monitor hemophilia but also for thrombophilia investigations. With the advent of chromogenic substrate technology, accurate and sensitive methods are available for quality control and for the clinical coagulation laboratory.

Concentrated FVIII from plasma or recombinant FVIII can be given to hemophiliacs to restore hemostasis. Factor VIII Market is classified, by type into Recombinant Factor VIII, Plasma-derived Factor VIII. Factor VIII Market is classified, by disease management into Prophylaxis, On-demand Therapy, and Inhibitor Therapy. Prophylaxis segment accounted for the largest market share of the Factor VIII Market in terms of revenue. The treatment involves the steady infusion of clotting factors in patients to maintain their levels higher at all times.

On-demand therapy segment is expected to grow at fastest pace over the forecast period. This treatment route is appropriate when bleeding needs to be arrested as soon as it begins and prevents its spread to joints and muscles. The slow acting on-demand hemophilia therapeutics for disease management finds important market opportunities in developing countries, where market penetration is increasing gradually.

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